DeveloGen offers preclinical contract services for metabolic diseases. The service portfolio includes in vivo and in vitro pharmacology, assay development as well as consulting activities.

Over 10 years of experience

• Obesity
• Diabetes
• Diabetic complications
• Related metabolic and endocrine disorders

• Target identification and validation
• Assay development and screening
• Hit-to-lead and lead optimization
• In vitro and in vivo pharmacology

Contract services for metabolic diseases

• Pharmacokinetic studies
• Acute and subchronic efficacy pharmacology
• Animal models for obesity, diabetes, diabetic complications
• Hyperinsulinemic euglycemic clamp studies
• Broad range of standard parameters and disease-specific readouts
• Basic safety assessments

• Assay development and screening for HTS, H2L and LO programs including biochemical and cellular assay platforms
• Target validation in various metabolically relevant adipocytes and pancreatic islet beta cells
• Mechanism-of-Action studies

• Scientific support for relevant disease models and reference compounds
• Advice on study design including readouts and reference standards
• Project management
• Preparation of preclinical efficacy package for IND submission

 To request our services flyer please contact us here.